Agile Sciences’ technology is based off of a marine natural product, ageliferin.
Ageliferin is produced and secreted by a marine sponge, Agelas conifera, and prevents bacterial colonization of the sponge.
Agile Sciences has identified and characterized the active pharmacophore of ageliferin resulting in an extensive library of synthetic small molecules that are active against a wide range of Gram-positive and Gram-negative bacteria that are relevant to pharmaceutical, industrial, and agricultural applications.
Agile Sciences is developing novel 2-aminoimidazole (2-AI) compounds to enhance antimicrobial efficacy against difficult-to-treat bacterial infections.
The 2-AI compounds act via a novel mechanism of action to interfere with the abilities of bacteria to sense and respond to their environment. This interference strips the ability of the bacteria to mount protective responses, such as biofilm formation and the expression of antibiotic resistance traits, to environmental threats. The bacteria are rendered defenseless and can be effectively eliminated with traditional antimicrobial approaches.