Publications

Selected publications by Agile's cofounders:

  • Su, Z.; Peng, L.; Worthington, R.J.; and Melander C. "Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual Antibiofilm/Antibiotic Resensitization Activity." ChemMedChem, 2011, 6, 2243-2251.
  • Harris, T.L.; Worthington, R.J.; and Melander C. "A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library." Bioorganic & Medicinal Chemistry Letters, 2011, 21 (15), 4516-4519.
  • Liu, C.; Worthington, R.J.; Melander, C.; and Wu, H. "A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms." Antimicrobial Agents and Chemotherapy, 2011, 55 (6), 2679-2687.
  • Rogers, S.A.; Lindsey, E.A.; Whitehead, D.C.; Mullikin, T.; and Melander, C. " Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents." Bioorganic and Medicinal Chemistry Letters, 2011, 21 (4), 1257-1260.
  • Bunders, C.; Cavanagh, J.; and Melander, C. "Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms." Organic and Biomolecular Chemistry, 2011, 9 (15), 5476-5481.
  • Peng, L.; DeSousa, J.; Su, Z.; Novak, B.M.; Nevzorov, A.A.; Garland, E.R.; and Melander, C. " Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit." Chemical Communications, 2011, 47 (17), 4896-4898.
  • Reyes, S.; Huigens, R.W.; Su, Z; Simon, M.L.; and Melander, C. "Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling." Organic and Biomolecular Chemistry, 2011, 9 (8), 3041-3049.
  • Reed, C.S.; Huigens, R.W.; Rogers, S.A.; and Melander, C. "Modulating the development of E. coli biofilms with 2-aminoimidazoles." Biorganic and Medicinal Chemistry Letters, 2011, 20 (21), 6310-6312.
  • Su, Z.; Rogers, S.A.; McCall, W.S.; Smith, A.C.; Ravishankar, S.; Mullikin, T.; and Melander, C. "A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity." Organic and Biomolecular Chemistry, 2010, 8 (12), 2814-2822.
  • Rogers, S.A.; Huigens, R.W.; Cavanagh, J.; and Melander, C. "Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents." Antimicrobial Agents and Chemotherapy, 2010, 54 (5), 2112-2118.
  • Rogers, S.A.; Bero, J.D.; and Melander, C. "Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents." ChemBioChem, 2010, 11 (3), 396-410.
  • Bunders, C.A.; Richards, J.J.; and Melander, C. "Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria." Bioorganic & Medicinal Chemistry Letters, 2010, 20 (12), 3797-3800.
  • Rogers, S.A.; Whitehead, D.C.; Millikin, T.; and Melander, C. "Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives." Organic and Biomolecular Chemistry, 2010, 8 (17), 3857-3859.
  • Huigens, R.W.; Reyes, S.; Reed, C.S.; Bunders, C.; Rogers, S.A.; Steinhauer, A.T.; and Melander, C. "The Chemical Synthesis and Antibiotic Activity of a Diverse Library of 2-Aminobenzimidazole Small Molecules Against MRSA and Multidrug-Resistant A. baumannii." Bioorganic & Medicinal Chemistry, 2010, 18 (2), 663-674.
  • Richards, J.J. and Melander, C. "Controlling Bacterial Biofilms." (invited review) Chem Bio Chem, 2009, 10 (14), 2287-2294.
  • Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.; Ballard, T.E.; Cavanagh, J.; and Melander, C. "Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity." Journal of Medicinal Chemistry, 2009, 52 (15), 4582-4585.
  • Rogers, S.A.; Huigens, R.W.; and Melander, C. "A 2-Aminobenzimidazole that Inhibits and Disperses Gram-Positive Biofilms Through a Zinc-Dependent Mechanism." Journal of the American Chemical Society, 2009, 131 (29), 9868–9869.
  • Melander, C; Moeller, P.D.R.; Ballard, T.E.; Richards, J.J.; Huigens, R.W.; and Cavanagh, J. "Evaluation of Dihydrooroidin as an Antifouling Additive in Marine Paint." International Biodeterioration and Biodegradation, 2009, 63, 529-532.
  • Ballard, T. E.; Richards, J.J.; Aquino, A.; Reed, C.S.; and Melander, C. "Anti-biofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation." Journal of Organic Chemistry, 2009, 74 (4), 1755-1758.
  • Huigens, R.W.; Rogers, S.A.; Steinhauer, A.T.; and Melander, C. "Inhibition of Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa Biofilms with a Class of TAGE-Triazole Conjugates." Organic and Biomolecular Chemistry, 2009, 7, 794-802.
  • Rogers, S. A.; Krayer, M.; Lindsey, J.S.; and Melander, C. "Tandem Dispersion and Killing of Bacteria from a Biofilm." Organic and Biomolecular Chemistry, 2009, 7, 603-606.
  • Ballard, T. E.; Richards, J.J.; Wolfe, A.L.; and Melander, C. "Synthesis and Anti-biofilm Activity of a Second Generation Reverse Amide Oroidin Library: An SAR Study." Chemistry a European Journal, 2008, 14 (34), 10745-10761.
  • Richards, J.J.; Reed, C.S.; and Melander, C. "Effects of N-Pyrrole Substitution on the Anti-Biofilm Activities of Oroidin Derivatives Against Acinetobacter baumannii." Bioorganic & Medicinal Chemistry Letters, 2008, 18 (15), 4325-4327.
  • Richards, J.J. and Melander, C. "Synthesis of a 2-Aminoimidazole Library for Anti-Biofilm Screening Utilizing the Sonogashira Reaction." Journal of Organic Chemistry, 2008, 73 (13), 5191-5193.
  • Rogers, S.A. and Melander, C. "Construction and Screening of a 2-Aminoimidazole Library Accessed by [3+2] Click Chemistry Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms Across Order, Class and Phylum." Angewandte Chemie International Edition, 2008, 47 (28), 5229-5231.
  • Richards, J.J.; Ballard, T.E.; Huigens, R.W.; and Melander, C. "Synthesis and Screening of an Oroidin Library Against Pseudomonas aeruginosa Biofilms." ChemBioChem, 2008, 9 (8), 1267-1279.
  • Huigens, R.W.; Ma, L.; Gambino, C.; Basso, A.; Moeller, P.D.R.; Cavanagh, J.; Wozniak, D.J.; and Melander, C. "Control of Bacterial Biofilms with Marine Alkaloid Derivatives." Molecular BioSystems, 2008, 4 (6), 614-621.
  • Richards, J.J.; Ballard, T.E.; and Melander, C. "Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms with Reverse Amide 2-Aminoimidazole Oroidin Analogues." Organic and Biomolecular Chemistry. 2008, 6, 1356-1363.
  • Richards, J.J.; Huigens, R.W.; Ballard, T.E.; Basso, A.; Cavanagh, J.; and Melander, C. "Inhibition and Dispersion of Proteobacterial Biofilms." Chemical Communications. 2008, 14, 1698 - 1700.
  • Huigens, R.W.; Richards, J.J.; Parise, G.; Ballard, T.E.; Zeng, W.; Deora, R.; and Melander, C. "Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues." Journal of the American Chemical Society. 2007, 129 (22), 6966-6967.