Leave bacteria defenses against antibiotics
Agile Sciences is developing novel 2-aminoimidazole (2-AI) compounds to enhance antimicrobial efficacy against difficult-to-treat bacterial infections. The 2-AI compounds act via a novel mechanism of action to interfere with the abilities of bacteria to sense and respond to their environment. This interference strips the ability of the bacteria to mount protective responses, such as biofilm formation and the expression of antibiotic resistance traits, to environmental threats. The bacteria are rendered defenseless and can be effectively eliminated with traditional antimicrobial approaches.