Our Technology

Leave bacteria defenses against antibiotics

Agile Sciences is developing novel 2-aminoimidazole (2-AI) compounds to enhance antimicrobial efficacy against difficult-to-treat bacterial infections. The 2-AI compounds act via a novel mechanism of action to interfere with the abilities of bacteria to sense and respond to their environment. This interference strips the ability of the bacteria to mount protective responses, such as biofilm formation and the expression of antibiotic resistance traits, to environmental threats. The bacteria are rendered defenseless and can be effectively eliminated with traditional antimicrobial approaches.

  2-aminoimidazole (2-AI) compounds

2-AI compounds are based on a marine natural product which is produced and secreted by a marine sponge. These compounds prevent bacterial colonization of the sponge. Agile Sciences has identified and characterized the biologically active region of this natural product and used it to synthesize libraries of small molecules that break resistance traits in both Gram-negative and Gram-positive bacteria. The technology lends itself to applications in human health, animal health, the agricultural arena and industry/surfaces. 

"Antibiotic resistance is putting the achievements of modern medicine at risk. Organ transplantations, chemotherapy and surgeries such as caesarean sections become much more dangerous without effective antibiotics for the prevention and treatment of infections."

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World Health Organization